Aberrant repair initiated by mismatch-specific thymine-DNA glycosylases provides a mechanism for the mutational bias observed in CpG islands

The human thymine-DNA glycosylase (TDG) initiates the base excision repair (BER) pathway to remove spontaneous and induced DNA base damage. It was first biochemically characterized for its ability to remove T mispaired with G in CpG context. TDG is involved in the epigenetic regulation of gene expre...

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Detalhes bibliográficos
Main Authors: Talhaoui, Ibtissam, Couve, Sophie, Gros, Laurent, Ishchenko, Alexander A., Matkarimov, Bakhyt, Saparbaev, Murat K.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041421/
https://ncbi.nlm.nih.gov/pubmed/24692658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku246
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