Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA

Active DNA demethylation in mammals occurs via hydroxylation of 5-methylcytosine to 5-hydroxymethylcytosine (5hmC) by the ten-eleven translocation family of proteins (TETs). 5hmC residues in DNA can be further oxidized by TETs to 5-carboxylcytosines and/or deaminated by the Activation Induced Deamin...

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Detalhes bibliográficos
Main Authors: Moréra, Solange, Grin, Inga, Vigouroux, Armelle, Couvé, Sophie, Henriot, Véronique, Saparbaev, Murat, Ishchenko, Alexander A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479182/
https://ncbi.nlm.nih.gov/pubmed/22848106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks714
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