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Oxidatively Generated Guanine(C8)-Thymine(N3) Intrastrand Cross-links in Double-stranded DNA Are Repaired by Base Excision Repair Pathways
Oxidatively generated guanine radical cations in DNA can undergo various nucleophilic reactions including the formation of C8-guanine cross-links with adjacent or nearby N3-thymines in DNA in the presence of O(2). The G*[C8-N3]T* lesions have been identified in the DNA of human cells exposed to oxid...
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| Publié dans: | J Biol Chem |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4505527/ https://ncbi.nlm.nih.gov/pubmed/25903131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.647487 |
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