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Review of Poly (ADP-ribose) Polymerase (PARP) Mechanisms of Action and Rationale for Targeting in Cancer and Other Diseases

Poly (ADP-ribose) polymerases (PARPs) are a family of related enzymes that share the ability to catalyze the transfer of ADP-ribose to target proteins. PARPs play an important role in various cellular processes, including modulation of chromatin structure, transcription, replication, recombination,...

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Detalhes bibliográficos
Publicado no:Crit Rev Eukaryot Gene Expr
Main Authors: Morales, Julio C., Li, Longshan, Fattah, Farjana J., Dong, Ying, Bey, Erik A., Patel, Malina, Gao, Jinming, Boothman, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4806654/
https://ncbi.nlm.nih.gov/pubmed/24579667
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