Depleting tumor-NQO1 Potentiates Anoikis and Inhibits Growth of NSCLC

Por Madajewski, Brian, Boatman, Michael A., Chakrabarti, Gaurab, Boothman, David A., Bey, Erik A.
Publicado no Mol Cancer Res (2015)

β-Lapachone-containing PEG-PLA Polymer Micelles as Novel Nanotherapeutics against NQO1-Overexpressing Tumor Cells

Por Blanco, Elvin, Bey, Erik A., Dong, Ying, Weinberg, Brent D., Sutton, Damon M., Boothman, David A., Gao, Jinming
Publicado em 2007

Superparamagnetic Iron Oxide Nanoparticles: Amplifying ROS Stress to Improve Anticancer Drug Efficacy

Por Huang, Gang, Chen, Huabing, Dong, Ying, Luo, Xiuquan, Yu, Haijun, Moore, Zachary, Bey, Erik A., Boothman, David A., Gao, Jinming
Publicado em 2013

Hemoglobin-Based Oxygen Carrier Mitigates Transfusion-Mediated Pancreas Cancer Progression

Por Lo, Karen K., Bey, Erik A., Patra, Biswantha, Benson, Douglas D., Boothman, David A., Silliman, Christopher C., Barnett, Carlton C.
Publicado em 2013

Review of Poly (ADP-ribose) Polymerase (PARP) Mechanisms of Action and Rationale for Targeting in Cancer and Other Diseases

Por Morales, Julio C., Li, Longshan, Fattah, Farjana J., Dong, Ying, Bey, Erik A., Patel, Malina, Gao, Jinming, Boothman, David A.
Publicado no Crit Rev Eukaryot Gene Expr (2014)

Dual PI3K/mTOR blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations

Por Konstantinidou, Georgia, Bey, Erik A., Rabellino, Andrea, Schuster, Katja, Maira, Michael S., Gazdar, Adi F., Amici, Augusto, Boothman, David A., Scaglioni, Pier Paolo
Publicado em 2009

Intratumoral Delivery of β-Lapachone via Polymer Implants for Prostate Cancer Therapy

Por Dong, Ying, Chin, Shook-Fong, Blanco, Elvin, Bey, Erik A, Kabbani, Wareef, Xie, Xian-Jin, Bornmann, William G., Boothman, David A., Gao, Jinming
Publicado em 2009

Prostate cancer radiosensitization through PARP-1 hyperactivation

Por Dong, Ying, Bey, Erik A., Li, Long-Shan, Kabbani, Wareef, Yan, Jingsheng, Xie, Xian-Jin, Hsieh, Jer-Tsong, Gao, Jinming, Boothman, David A.
Publicado em 2010

In vivo Off-Resonance Saturation Magnetic Resonance Imaging of α(v)β(3)-Targeted Superparamagnetic Nanoparticles

Por Khemtong, Chalermchai, Kessinger, Chase W., Ren, Jimin, Bey, Erik A., Yang, Su-Geun, Guthi, Jagadeesh Setti, Boothman, David A., Sherry, A. Dean, Gao, Jinming
Publicado em 2009

An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by β-lapachone

Por Bey, Erik A., Bentle, Melissa S., Reinicke, Kathryn E., Dong, Ying, Yang, Chin-Rang, Girard, Luc, Minna, John D., Bornmann, William G., Gao, Jinming, Boothman, David A.
Publicado em 2007

NQO1-dependent, tumor-selective radiosensitization of non-small cell lung cancers

Por Motea, Edward A., Huang, Xiumei, Singh, Naveen, Kilgore, Jessica, Williams, Noelle, Xie, Xian-Jin, Gerber, David E., Beg, Muhammad Shaalan, Bey, Erik A., Boothman, David A.
Publicado no Clin Cancer Res (2019)

Targeting Base Excision Repair in Cancer: NQO1-Bioactivatable Drugs Improve Tumor Selectivity and Reduce Treatment Toxicity Through Radiosensitization of Human Cancer

Por Starcher, Colton L., Pay, S. Louise, Singh, Naveen, Yeh, I-Ju, Bhandare, Snehal B., Su, Xiaolin, Huang, Xiumei, Bey, Erik A., Motea, Edward A., Boothman, David A.
Publicado no Front Oncol (2020)

β-Lapachone Micellar Nanotherapeutics for Non-Small Cell Lung Cancer Therapy

Por Blanco, Elvin, Bey, Erik A., Khemtong, Chalermchai, Yang, Su-Geun, Setti-Guthi, Jagadeesh, Chen, Huabing, Kessinger, Chase W., Carnevale, Kevin A., Bornmann, William G., Boothman, David A., Gao, Jinming
Publicado em 2010

Modulating Endogenous NQO1 Levels Identifies Key Regulatory Mechanisms of Action of β-Lapachone for Pancreatic Cancer Therapy

Por Li, Long Shan, Bey, Erik A., Dong, Ying, Meng, Jieru, Patra, Biswanath, Yan, Jingsheng, Xie, Xian-Jin, Brekken, Rolf A., Barnett, Carlton C., Bornmann, William G., Gao, Jinming, Boothman, David A.
Publicado no Clin Cancer Res (2011)

An NQO1 Substrate with Potent Antitumor Activity That Selectively Kills by PARP1-Induced Programmed Necrosis

Por Huang, Xiumei, Dong, Ying, Bey, Erik A., Kilgore, Jessica A., Bair, Joseph S., Li, Long-Shan, Patel, Malina, Parkinson, Elizabeth I., Wang, Yiguang, Williams, Noelle S., Gao, Jinming, Hergenrother, Paul J., Boothman, David A.
Publicado no Cancer Res (2012)

Catalase abrogates β-lapachone-induced PARP1 hyperactivation-directed programmed necrosis in NQO1-positive breast cancers

Por Bey, Erik A., Reinicke, Kathryn E., Srougi, Melissa C., Varnes, Marie, Anderson, Vernon, Pink, John J., Li, Long Shan, Patel, Malina, Cao, Lifen, Moore, Zachary, Rommel, Amy, Boatman, Michael, Lewis, Cheryl, Euhus, David M., Bornmann, William G., Buchsbaum, Donald J., Spitz, Douglas R., Gao, Jinming, Boothman, David A.
Publicado em 2013

Tumor-Selective, Futile Redox Cycle-Induced Bystander Effects Elicited by NQO1 Bioactivatable Radiosensitizing Drugs in Triple-Negative Breast Cancers

Por Cao, Lifen, Li, Long Shan, Spruell, Christopher, Xiao, Ling, Chakrabarti, Gaurab, Bey, Erik A., Reinicke, Kathryn E., Srougi, Melissa C., Moore, Zachary, Dong, Ying, Vo, Peggy, Kabbani, Wareef, Yang, Chin-Rang, Wang, Xiaoyu, Fattah, Farjana, Morales, Julio C., Motea, Edward A., Bornmann, William G., Yordy, John S., Boothman, David A.
Publicado em 2014

Y Chromosome LncRNA are involved in Radiation Response of Male Non-Small Cell Lung Cancer Cells

Por Brownmiller, Tayvia, Juric, Jamie A., Ivey, Abby D., Harvey, Brandon M., Westemeier, Emily S., Winters, Michael T., Stevens, Alyson M., Stanley, Alana N., Hayes, Karen E., Sprowls, Samuel A., Ammer, Amanda S. Gatesman, Walker, Mackenzee, Bey, Erik A., Wu, Xiaoliang, Lim, Zuan-Fu, Zhu, Lin, Wen, Sijin, Hu, Gangqing, Ma, Patrick C., Martinez, Ivan
Publicado no Cancer Res (2020)

Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase (PARP) Inhibitors

Por Huang, Xiumei, Motea, Edward A., Moore, Zachary R., Yao, Jun, Dong, Ying, Chakrabarti, Gaurab, Kilgore, Jessica A., Silvers, Molly A., Patidar, Praveen L., Cholka, Agnieszka, Fattah, Farjana, Cha, Yoonjeong, Anderson, Glenda G., Kusko, Rebecca, Peyton, Michael, Yan, Jingsheng, Xie, Xian-Jin, Sarode, Venetia, Williams, Noelle S., Minna, John D., Beg, Muhammad, Gerber, David E., Bey, Erik A., Boothman, David A.
Publicado no Cancer Cell (2016)