An NQO1 Substrate with Potent Antitumor Activity That Selectively Kills by PARP1-Induced Programmed Necrosis

Agents, such as β-lapachone, that target the redox enzyme, NAD(P)H:quinone oxidoreductase 1 (NQO1), to induce programmed necrosis in solid tumors have shown great promise, but more potent tumor-selective compounds are needed. Here, we report that deoxynyboquinone kills a wide spectrum of cancer cell...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Huang, Xiumei, Dong, Ying, Bey, Erik A., Kilgore, Jessica A., Bair, Joseph S., Li, Long-Shan, Patel, Malina, Parkinson, Elizabeth I., Wang, Yiguang, Williams, Noelle S., Gao, Jinming, Hergenrother, Paul J., Boothman, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4795165/
https://ncbi.nlm.nih.gov/pubmed/22532167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-3135
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