An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by β-lapachone

Lung cancer is the number one cause of cancer-related deaths in the world. Patients treated with current chemotherapies for non-small-cell lung cancers (NSCLCs) have a survival rate of ≈15% after 5 years. Novel approaches are needed to treat this disease. We show elevated NAD(P)H:quinone oxidoreduct...

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Detalhes bibliográficos
Main Authors: Bey, Erik A., Bentle, Melissa S., Reinicke, Kathryn E., Dong, Ying, Yang, Chin-Rang, Girard, Luc, Minna, John D., Bornmann, William G., Gao, Jinming, Boothman, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1913860/
https://ncbi.nlm.nih.gov/pubmed/17609380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702176104
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