Modulating Endogenous NQO1 Levels Identifies Key Regulatory Mechanisms of Action of β-Lapachone for Pancreatic Cancer Therapy

PURPOSE: Pancreatic cancer is the fourth leading cause of cancer-related deaths, in which the 5-year survival rate is less than 5%. Current standard of care therapies offer little selectivity and high toxicity. Novel, tumor-selective approaches are desperately needed. Although prior work suggested t...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Li, Long Shan, Bey, Erik A., Dong, Ying, Meng, Jieru, Patra, Biswanath, Yan, Jingsheng, Xie, Xian-Jin, Brekken, Rolf A., Barnett, Carlton C., Bornmann, William G., Gao, Jinming, Boothman, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4806682/
https://ncbi.nlm.nih.gov/pubmed/21224367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-1983
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