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β-Lapachone-containing PEG-PLA Polymer Micelles as Novel Nanotherapeutics against NQO1-Overexpressing Tumor Cells
β-Lapachone (β-lap) is a novel anticancer agent that is bioactivated by NADP(H): quinone oxidoreductase 1 (NQO1), an enzyme overexpressed in a variety of tumors. Despite its therapeutic promise, the poor aqueous solubility of β-lap hinders its preclinical evaluation and clinical translation. Our obj...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2007
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2064869/ https://ncbi.nlm.nih.gov/pubmed/17574288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2007.04.014 |
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