Tumor-Selective, Futile Redox Cycle-Induced Bystander Effects Elicited by NQO1 Bioactivatable Radiosensitizing Drugs in Triple-Negative Breast Cancers

Aims: β-Lapachone (β-lap), a novel radiosensitizer with potent antitumor efficacy alone, selectively kills solid cancers that over-express NAD(P)H:quinone oxidoreductase 1 (NQO1). Since breast or other solid cancers have heterogeneous NQO1 expression, therapies that reduce the resistance (e.g., NQO1...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Cao, Lifen, Li, Long Shan, Spruell, Christopher, Xiao, Ling, Chakrabarti, Gaurab, Bey, Erik A., Reinicke, Kathryn E., Srougi, Melissa C., Moore, Zachary, Dong, Ying, Vo, Peggy, Kabbani, Wareef, Yang, Chin-Rang, Wang, Xiaoyu, Fattah, Farjana, Morales, Julio C., Motea, Edward A., Bornmann, William G., Yordy, John S., Boothman, David A.
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2014
Fag:
Forum Original Research Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060774/
https://ncbi.nlm.nih.gov/pubmed/24512128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2013.5462
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker