NQO1-mediated tumor-selective lethality and radiosensitization for head and neck cancer

Ionizing radiation (IR) is a key therapeutic regimen for many head and neck cancers (HNCs). However, the 5-year overall survival rate for locally-advanced HNCs is ∼50% and better therapeutic efficacy is needed. NAD(P)H:quinone oxidoreductase 1 (NQO1) is over-expressed in many cancers, and β-lapachon...

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Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: Li, Long-Shan, Reddy, Srilakshmi, Lin, Zhen-Hua, Liu, Shuangping, Park, Hyunsil, Chun, Stephen G., Bornmann, William G., Thibodeaux, Joel, Yan, Jingsheng, Chakrabarti, Gaurab, Xie, Xian-Jin, Sumer, Baran D., Boothman, David A., Yordy, John S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5123441/
https://ncbi.nlm.nih.gov/pubmed/27196777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0765
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