Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform

Anti-cancer topoisomerase I (Top1) inhibitors (camptothecin and its clinical derivatives irinotecan and topotecan, and the indenoisoquinolines) induce lethal DNA lesions by stabilizing Top1-DNA cleavage complex (Top1cc). These lesions are repaired by parallel repair pathways including the tyrosyl-DN...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Murai, Junko, Marchand, Christophe, Shahane, Sampada A., Sun, Hongmao, Huang, Ruili, Zhang, Yiping, Chergui, Adel, Ji, Jiuping, Doroshow, James H., Jadhav, Ajit, Takeda, Shunichi, Xia, Menghang, Pommier, Yves
Formato: Artigo
Idioma:Inglês
Publicado: 2014
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125495/
https://ncbi.nlm.nih.gov/pubmed/24794403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2014.03.006
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares