Biochemical assays for the discovery of TDP1 inhibitors

Drug screening against novel targets is warranted to generate biochemical probes and new therapeutic drug leads. Tyrosyl-DNA-phosphodiesterases 1 and 2 (TDP1 and TDP2) are two DNA repair enzymes that have yet to be successfully targeted. TDP1 repairs topoisomerase I-, alkylation-, and chain terminat...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Marchand, Christophe, Huang, Shar-yin N., Dexheimer, Thomas S., Lea, Wendy A., Mott, Bryan T., Chergui, Adel, Naumova, Alena, Stephen, Andrew G., Rosenthal, Andrew S., Rai, Ganesha, Murai, Junko, Gao, Rui, Maloney, David J., Jadhav, Ajit, Jorgensen, William L., Simeonov, Anton, Pommier, Yves
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4126877/
https://ncbi.nlm.nih.gov/pubmed/25024006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-0952
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki