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Evaluation of Quinazoline analogues as Glucocerebrosidase Inhibitors with Chaperone activity
Gaucher disease is a Lysosomal Storage Disorder (LSD) caused by deficiency in the enzyme glucocerebrosidase (GC). Small molecule chaperones of protein folding and translocation have been proposed as a promising therapeutic approach to this LSD. Most small molecule chaperones described in the literat...
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| Main Authors: | , , , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3103057/ https://ncbi.nlm.nih.gov/pubmed/21250698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1008902 |
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