Evaluation of Quinazoline analogues as Glucocerebrosidase Inhibitors with Chaperone activity

Gaucher disease is a Lysosomal Storage Disorder (LSD) caused by deficiency in the enzyme glucocerebrosidase (GC). Small molecule chaperones of protein folding and translocation have been proposed as a promising therapeutic approach to this LSD. Most small molecule chaperones described in the literat...

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Main Authors: Marugan, Juan J., Zheng, Wei, Motabar, Omid, Southall, Noel, Goldin, Ehud, Westbroek, Wendy, K.Stubblefield, Barbara, Sidransky, Ellen, Aungst, Ronald A., Lea, Wendy A., Simeonov, Anton, Leister, William, Austin, Christopher P.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103057/
https://ncbi.nlm.nih.gov/pubmed/21250698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1008902
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