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A high throughput glucocerebrosidase assay using the natural substrate glucosylceramide
Glucocerebrosidase is a lysosomal enzyme that catalyzes the hydrolysis of glucosylceramide to form ceramide and glucose. A deficiency of lysosomal glucocerebrosidase due to genetic mutations results in Gaucher disease, in which glucosylceramide accumulates in the lysosomes of certain cell types. Alt...
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| Autores principales: | , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3351006/ https://ncbi.nlm.nih.gov/pubmed/22033823 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00216-011-5496-z |
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