Structure-Mechanism Insights and the Role of Nitric Oxide Donation Guide the Development of Oxadiazole-2-Oxides as Therapeutic Agents against Schistosomiasis

Schistosomiasis is a chronic parasitic disease affecting hundreds of millions of individuals worldwide. Current treatment depends on a single agent, praziquantel, raising concerns of emergence of resistant parasites. Here, we continue our explorations of an oxadiazole-2-oxide class of compounds we r...

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Hlavní autoři: Rai, Ganesha, Sayed, Ahmed A., Lea, Wendy A., Luecke, Hans, Chakrapani, Harinath, Prast-Nielsen, Stefanie, Jadhav, Ajit, Leister, William, Shen, Min, Inglese, James, Austin, Christopher P., Keefer, Larry, Arnér, Elias S. J., Simeonov, Anton, Maloney, David J., Williams, David L., Thomas, Craig J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772170/
https://ncbi.nlm.nih.gov/pubmed/19761212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901021k
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