Oxadiazole 2-oxides are toxic to the human hookworm, Ancylostoma ceylanicum, however glutathione reductase is not the primary target

Hookworm disease, characterized by severe anemia and cognitive and growth delays, currently affects an estimated 740 million people worldwide. Despite the prevalence of this parasitic disease, few effective drug therapies are in use today, and the heavy reliance upon benzimidazoles highlights the ne...

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Autors principals: Treger, Rebecca S., Cook, Aaron, Rai, Ganesha, Maloney, David J., Simeonov, Anton, Jadhav, Ajit, Thomas, Craig J., Williams, David L., Cappello, Michael, Vermeire, Jon J.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404738/
https://ncbi.nlm.nih.gov/pubmed/22844653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2012.05.001
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