Discovery of Potent and Selective Inhibitors of Human Reticulocyte 15- Lipoxygenase-1

There are a variety of lipoxygenases in the human body (hLO), each having a distinct role in cellular biology. Human reticulocyte 15-Lipoxygenase-1 (15-hLO-1), which catalyzes the dioxygenation of 1,4-cis,cis-pentadiene-containing polyunsaturated fatty acids, is implicated in a number of diseases in...

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Hauptverfasser: Rai, Ganesha, Kenyon, Victor, Jadhav, Ajit, Schultz, Lena, Armstrong, Michelle, Jameson, J Brian, Hoobler, Eric, Leister, William, Simeonov, Anton, Holman, Theodore R., Maloney, David J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966298/
https://ncbi.nlm.nih.gov/pubmed/20866075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1008852
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