Discovery of Potent and Selective Inhibitors of Human Platelet type 12-Lipoxygenase

We report the discovery of novel small molecule inhibitors of platelet type 12-human lipoxygenase, which display nanomolar activity against the purified enzyme, using a quantitative high throughput screen (qHTS) on a library of 153,607 compounds. These compounds also exhibit excellent specificity, &...

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Hauptverfasser: Kenyon, Victor, Rai, Ganesha, Jadhav, Ajit, Schultz, Lena, Armstrong, Michelle, Jameson, J. Brian, Perry, Steven, Joshi, Netra, Bougie, James M., Leister, William, Taylor-Fishwick, David A., Nadler, Jerry L., Holinstat, Michael, Simeonov, Anton, Maloney, David J., Holman, Theodore R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150642/
https://ncbi.nlm.nih.gov/pubmed/21739938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm2005089
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