Synthesis and Structure–Activity Relationship Studies of 4-((2-Hydroxy-3-methoxybenzyl)amino)benzenesulfonamide Derivatives as Potent and Selective Inhibitors of 12-Lipoxygenase

[Image: see text] Human lipoxygenases (LOXs) are a family of iron-containing enzymes which catalyze the oxidation of polyunsaturated fatty acids to provide the corresponding bioactive hydroxyeicosatetraenoic acid (HETE) metabolites. These eicosanoid signaling molecules are involved in a number of ph...

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Autori principali: Luci, Diane K., Jameson, J. Brian, Yasgar, Adam, Diaz, Giovanni, Joshi, Netra, Kantz, Auric, Markham, Kate, Perry, Steve, Kuhn, Norine, Yeung, Jennifer, Kerns, Edward H., Schultz, Lena, Holinstat, Michael, Nadler, Jerry L., Taylor-Fishwick, David A., Jadhav, Ajit, Simeonov, Anton, Holman, Theodore R., Maloney, David J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3967794/
https://ncbi.nlm.nih.gov/pubmed/24393039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm4016476
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