12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity

Following initial platelet activation, arachidonic acid is metabolised by cyclooxygenase-1 and 12-lipoxygenase (12-LOX). While the role of 12-LOX in the platelet is not well defined, recent evidence suggests that it may be important for regulation of platelet activity and is agonist-specific in the...

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Главные авторы: Yeung, Jennifer, Apopa, Patrick L., Vesci, Joanne, Stolla, Moritz, Rai, Ganesha, Simeonov, Anton, Jadhav, Ajit, Fernandez-Perez, Pilar, Maloney, David J., Boutaud, Olivier, Holman, Theodore R., Holinstat, Michael
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3960303/
https://ncbi.nlm.nih.gov/pubmed/23784669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1160/TH13-01-0014
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