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12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity
Following initial platelet activation, arachidonic acid is metabolised by cyclooxygenase-1 and 12-lipoxygenase (12-LOX). While the role of 12-LOX in the platelet is not well defined, recent evidence suggests that it may be important for regulation of platelet activity and is agonist-specific in the...
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| Autores principales: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3960303/ https://ncbi.nlm.nih.gov/pubmed/23784669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1160/TH13-01-0014 |
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