Fab-arm exchange: What’s in a name?

Por Schuurman, Janine, Labrijn, Aran F., Parren, Paul W.H.I.
Publicado em 2012

Opening the door to innovation

Por Schuurman, Janine, Graus, Yvo F, Labrijn, Aran F, Ruuls, Sigrid R, Parren, Paul WHI
Publicado em 2014

Kinetic mechanism of controlled Fab-arm exchange for the formation of bispecific immunoglobulin G1 antibodies

Por Goulet, Dennis R., Orcutt, Steven J., Zwolak, Adam, Rispens, Theo, Labrijn, Aran F., de Jong, Rob N., Atkins, William M., Chiu, Mark L.
Publicado no J Biol Chem (2018)

A Novel Human Antibody against Human Immunodeficiency Virus Type 1 gp120 Is V1, V2, and V3 Loop Dependent and Helps Delimit the Epitope of the Broadly Neutralizing Antibody Immunog...

Por Zwick, Michael B., Kelleher, Robert, Jensen, Richard, Labrijn, Aran F., Wang, Meng, Quinnan, Jr., Gerald V., Parren, Paul W. H. I., Burton, Dennis R.
Publicado em 2003

Mutation of Y407 in the CH3 domain dramatically alters glycosylation and structure of human IgG

Por Rose, Rebecca J., van Berkel, Patrick H.C., van den Bremer, Ewald T.J., Labrijn, Aran F., Vink, Tom, Schuurman, Janine, Heck, Albert J.R., Parren, Paul W.H.I.
Publicado em 2013

Efficient Generation of Bispecific Murine Antibodies for Pre-Clinical Investigations in Syngeneic Rodent Models

Por Labrijn, Aran F., Meesters, Joyce I., Bunce, Matthew, Armstrong, Anthony A., Somani, Sandeep, Nesspor, Tom C., Chiu, Mark L., Altintaş, Işil, Verploegen, Sandra, Schuurman, Janine, Parren, Paul W. H. I.
Publicado no Sci Rep (2017)

Broadly Neutralizing Antibodies Targeted to the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 Glycoprotein gp41

Por Zwick, Michael B., Labrijn, Aran F., Wang, Meng, Spenlehauer, Catherine, Saphire, Erica Ollmann, Binley, James M., Moore, John P., Stiegler, Gabriela, Katinger, Hermann, Burton, Dennis R., Parren, Paul W. H. I.
Publicado em 2001

FcγR Binding and ADCC Activity of Human IgG Allotypes

Por de Taeye, Steven W., Bentlage, Arthur E. H., Mebius, Mirjam M., Meesters, Joyce I., Lissenberg-Thunnissen, Suzanne, Falck, David, Sénard, Thomas, Salehi, Nima, Wuhrer, Manfred, Schuurman, Janine, Labrijn, Aran F., Rispens, Theo, Vidarsson, Gestur
Publicado no Front Immunol (2020)

Broadly cross-reactive HIV-1-neutralizing human monoclonal Fab selected for binding to gp120–CD4–CCR5 complexes

Por Moulard, Maxime, Phogat, Sanjay K., Shu, Yuuei, Labrijn, Aran F., Xiao, Xiaodong, Binley, James M., Zhang, Mei-Yun, Sidorov, Igor A., Broder, Christopher C., Robinson, James, Parren, Paul W. H. I., Burton, Dennis R., Dimitrov, Dimiter S.
Publicado em 2002

Production of stable bispecific IgG1 by controlled Fab-arm exchange: Scalability from bench to large-scale manufacturing by application of standard approaches

Por Gramer, Michael J, van den Bremer, Ewald TJ, van Kampen, Muriel D, Kundu, Amitava, Kopfmann, Peter, Etter, Eric, Stinehelfer, David, Long, Justin, Lannom, Tom, Noordergraaf, Esther H, Gerritsen, Jolanda, Labrijn, Aran F, Schuurman, Janine, van Berkel, Patrick HC, Parren, Paul WHI
Publicado em 2013

Access of Antibody Molecules to the Conserved Coreceptor Binding Site on Glycoprotein gp120 Is Sterically Restricted on Primary Human Immunodeficiency Virus Type 1

Por Labrijn, Aran F., Poignard, Pascal, Raja, Aarti, Zwick, Michael B., Delgado, Karla, Franti, Michael, Binley, James, Vivona, Veronique, Grundner, Christoph, Huang, Chih-Chin, Venturi, Miro, Petropoulos, Christos J., Wrin, Terri, Dimitrov, Dimiter S., Robinson, James, Kwong, Peter D., Wyatt, Richard T., Sodroski, Joseph, Burton, Dennis R.
Publicado em 2003

DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing

Por Engelberts, Patrick J., Hiemstra, Ida H., de Jong, Bart, Schuurhuis, Danita H., Meesters, Joyce, Beltran Hernandez, Irati, Oostindie, Simone C., Neijssen, Joost, van den Brink, Edward N., Horbach, G. Jean, Verploegen, Sandra, Labrijn, Aran F., Salcedo, Theodora, Schuurman, Janine, Parren, Paul W.H.I, Breij, Esther C.W.
Publicado no EBioMedicine (2020)

Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange

Por Labrijn, Aran F., Meesters, Joyce I., de Goeij, Bart E. C. G., van den Bremer, Ewald T. J., Neijssen, Joost, van Kampen, Muriel D., Strumane, Kristin, Verploegen, Sandra, Kundu, Amitava, Gramer, Michael J., van Berkel, Patrick H. C., van de Winkel, Jan G. J., Schuurman, Janine, Parren, Paul W. H. I.
Publicado em 2013

Hinge-deleted IgG4 blocker therapy for acetylcholine receptor myasthenia gravis in rhesus monkeys

Por Losen, Mario, Labrijn, Aran F., van Kranen-Mastenbroek, Vivianne H., Janmaat, Maarten L., Haanstra, Krista G., Beurskens, Frank J., Vink, Tom, Jonker, Margreet, ‘t Hart, Bert A., Mané-Damas, Marina, Molenaar, Peter C., Martinez-Martinez, Pilar, van der Esch, Eline, Schuurman, Janine, de Baets, Marc H., Parren, Paul W. H. I.
Publicado no Sci Rep (2017)

In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation

Por Seshasayee, Dhaya, Lee, Wyne P., Zhou, Meijuan, Shu, Jean, Suto, Eric, Zhang, Juan, Diehl, Laurie, Austin, Cary D., Meng, Y. Gloria, Tan, Martha, Bullens, Sherron L., Seeber, Stefan, Fuentes, Maria E., Labrijn, Aran F., Graus, Yvo M.F., Miller, Lisa A., Schelegle, Edward S., Hyde, Dallas M., Wu, Lawren C., Hymowitz, Sarah G., Martin, Flavius
Publicado em 2007