Kinetic mechanism of controlled Fab-arm exchange for the formation of bispecific immunoglobulin G1 antibodies

Bispecific antibodies (bsAbs) combine the antigen specificities of two distinct Abs and demonstrate therapeutic promise based on novel mechanisms of action. Among the many platforms for creating bsAbs, controlled Fab-arm exchange (cFAE) has proven useful based on minimal changes to native Ab structu...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Goulet, Dennis R., Orcutt, Steven J., Zwolak, Adam, Rispens, Theo, Labrijn, Aran F., de Jong, Rob N., Atkins, William M., Chiu, Mark L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Molecular Biophysics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767869/
https://ncbi.nlm.nih.gov/pubmed/29150443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000303
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