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FcγR Binding and ADCC Activity of Human IgG Allotypes
Antibody dependent cellular cytotoxicity (ADCC) is an Fc-dependent effector function of IgG important for anti-viral immunity and anti-tumor therapies. NK-cell mediated ADCC is mainly triggered by IgG-subclasses IgG1 and IgG3 through the IgG-Fc-receptor (FcγR) IIIa. Polymorphisms in the immunoglobul...
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| Veröffentlicht in: | Front Immunol |
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| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Frontiers Media S.A.
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7218058/ https://ncbi.nlm.nih.gov/pubmed/32435243 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00740 |
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