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IgG Subclasses and Allotypes: From Structure to Effector Functions

Of the five immunoglobulin isotypes, immunoglobulin G (IgG) is most abundant in human serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ in their constant region, particularly in their hinges and upper CH2 domains. These regions are involved in binding to both...

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Hlavní autoři: Vidarsson, Gestur, Dekkers, Gillian, Rispens, Theo
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4202688/
https://ncbi.nlm.nih.gov/pubmed/25368619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2014.00520
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