Access of Antibody Molecules to the Conserved Coreceptor Binding Site on Glycoprotein gp120 Is Sterically Restricted on Primary Human Immunodeficiency Virus Type 1

Anti-human immunodeficiency virus type 1 (HIV-1) antibodies whose binding to gp120 is enhanced by CD4 binding (CD4i antibodies) are generally considered nonneutralizing for primary HIV-1 isolates. However, a novel CD4i-specific Fab fragment, X5, has recently been found to neutralize a wide range of...

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Main Authors: Labrijn, Aran F., Poignard, Pascal, Raja, Aarti, Zwick, Michael B., Delgado, Karla, Franti, Michael, Binley, James, Vivona, Veronique, Grundner, Christoph, Huang, Chih-Chin, Venturi, Miro, Petropoulos, Christos J., Wrin, Terri, Dimitrov, Dimiter S., Robinson, James, Kwong, Peter D., Wyatt, Richard T., Sodroski, Joseph, Burton, Dennis R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC228502/
https://ncbi.nlm.nih.gov/pubmed/12970440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.19.10557-10565.2003
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