Access of Antibody Molecules to the Conserved Coreceptor Binding Site on Glycoprotein gp120 Is Sterically Restricted on Primary Human Immunodeficiency Virus Type 1

Anti-human immunodeficiency virus type 1 (HIV-1) antibodies whose binding to gp120 is enhanced by CD4 binding (CD4i antibodies) are generally considered nonneutralizing for primary HIV-1 isolates. However, a novel CD4i-specific Fab fragment, X5, has recently been found to neutralize a wide range of...

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Bibliografische gegevens

Gepubliceerd in:	J Virol
Hoofdauteurs:	Labrijn, Aran F., Poignard, Pascal, Raja, Aarti, Zwick, Michael B., Delgado, Karla, Franti, Michael, Binley, James, Vivona, Veronique, Grundner, Christoph, Huang, Chih-Chin, Venturi, Miro, Petropoulos, Christos J., Wrin, Terri, Dimitrov, Dimiter S., Robinson, James, Kwong, Peter D., Wyatt, Richard T., Sodroski, Joseph, Burton, Dennis R.
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	American Society for Microbiology (ASM) 2003
Onderwerpen:	Pathogenesis and Immunity
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC228502/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12970440/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.19.10557-10565.2003
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