Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange

The promise of bispecific antibodies (bsAbs) to yield more effective therapeutics is well recognized; however, the generation of bsAbs in a practical and cost-effective manner has been a formidable challenge. Here we present a technology for the efficient generation of bsAbs with normal IgG structur...

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Bibliografiske detaljer
Main Authors:	Labrijn, Aran F., Meesters, Joyce I., de Goeij, Bart E. C. G., van den Bremer, Ewald T. J., Neijssen, Joost, van Kampen, Muriel D., Strumane, Kristin, Verploegen, Sandra, Kundu, Amitava, Gramer, Michael J., van Berkel, Patrick H. C., van de Winkel, Jan G. J., Schuurman, Janine, Parren, Paul W. H. I.
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 2013
Fag:	Biological Sciences
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3612680/ https://ncbi.nlm.nih.gov/pubmed/23479652 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220145110
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Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange

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