Production of stable bispecific IgG1 by controlled Fab-arm exchange: Scalability from bench to large-scale manufacturing by application of standard approaches

The manufacturing of bispecific antibodies can be challenging for a variety of reasons. For example, protein expression problems, stability issues, or the use of non-standard approaches for manufacturing can result in poor yield or poor facility fit. In this paper, we demonstrate the use of standard...

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Main Authors: Gramer, Michael J, van den Bremer, Ewald TJ, van Kampen, Muriel D, Kundu, Amitava, Kopfmann, Peter, Etter, Eric, Stinehelfer, David, Long, Justin, Lannom, Tom, Noordergraaf, Esther H, Gerritsen, Jolanda, Labrijn, Aran F, Schuurman, Janine, van Berkel, Patrick HC, Parren, Paul WHI
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896610/
https://ncbi.nlm.nih.gov/pubmed/23995617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.26233
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