Mutation of Y407 in the CH3 domain dramatically alters glycosylation and structure of human IgG

Antibody engineering is increasingly being used to influence the properties of monoclonal antibodies to improve their biotherapeutic potential. One important aspect of this is the modulation of glycosylation as a strategy to improve efficacy. Here, we describe mutations of Y407 in the CH3 domain of...

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Detalhes bibliográficos
Main Authors: Rose, Rebecca J., van Berkel, Patrick H.C., van den Bremer, Ewald T.J., Labrijn, Aran F., Vink, Tom, Schuurman, Janine, Heck, Albert J.R., Parren, Paul W.H.I.
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893232/
https://ncbi.nlm.nih.gov/pubmed/23406897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.23532
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