A Novel Human Antibody against Human Immunodeficiency Virus Type 1 gp120 Is V1, V2, and V3 Loop Dependent and Helps Delimit the Epitope of the Broadly Neutralizing Antibody Immunoglobulin G1 b12

The V1/V2 and V3 loops are proximal to the CD4 binding site (CD4bs) of human immunodeficiency virus type 1 (HIV-1) gp120 and undergo conformational change upon CD4 receptor engagement by the HIV-1 envelope spike. Nearly all of the reported monoclonal antibodies (MAbs) against the CD4bs exhibit a ver...

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Bibliographische Detailangaben
Hauptverfasser: Zwick, Michael B., Kelleher, Robert, Jensen, Richard, Labrijn, Aran F., Wang, Meng, Quinnan, Jr., Gerald V., Parren, Paul W. H. I., Burton, Dennis R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2003
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC156200/
https://ncbi.nlm.nih.gov/pubmed/12768015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.12.6965-6978.2003
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