Bypassing Phase Variation of Lipooligosaccharide (LOS): Using Heptose 1 Glycan Mutants To Establish Widespread Efficacy of Gonococcal Anti-LOS Monoclonal Antibody 2C7

od Chakraborti, Srinjoy, Gulati, Sunita, Zheng, Bo, Beurskens, Frank J., Schuurman, Janine, Rice, Peter A., Ram, Sanjay
Wydane w Infect Immun (2020)

Exhaustion of cytotoxic effector systems may limit mAb-based immunotherapy in cancer patients()

od Beurskens, Frank J., Lindorfer, Margaret A., Farooqui, Mohammed, Beum, Paul V., Engelberts, Patrick, Mackus, Wendy J.M., Parren, Paul W.H.I., Wiestner, Adrian, Taylor, Ronald P.
Wydane 2012

Ibrutinib interferes with the cell-mediated anti-tumor activities of therapeutic CD20 antibodies: implications for combination therapy

od Roit, Fabio Da, Engelberts, Patrick J., Taylor, Ronald P., Breij, Esther C.W., Gritti, Giuseppe, Rambaldi, Alessandro, Introna, Martino, Parren, Paul W.H.I., Beurskens, Frank J., Golay, Josée
Wydane w Haematologica (2015)

Antibodies That Efficiently Form Hexamers upon Antigen Binding Can Induce Complement-Dependent Cytotoxicity under Complement-Limiting Conditions

od Cook, Erika M., Lindorfer, Margaret A., van der Horst, Hilma, Oostindie, Simone, Beurskens, Frank J., Schuurman, Janine, Zent, Clive S., Burack, Richard, Parren, Paul W. H. I., Taylor, Ronald P.
Wydane w J Immunol (2016)

Synthetic DNA Delivery of an Optimized and Engineered Monoclonal Antibody Provides Rapid and Prolonged Protection against Experimental Gonococcal Infection

od Parzych, Elizabeth M., Gulati, Sunita, Zheng, Bo, Bah, Mamadou A., Elliott, Sarah T. C., Chu, Jacqueline D., Nowak, Nancy, Reed, George W., Beurskens, Frank J., Schuurman, Janine, Rice, Peter A., Weiner, David B., Ram, Sanjay
Wydane w mBio (2021)

The in vivo mechanism of action of CD20 monoclonal antibodies depends on local tumor burden

od Boross, Peter, Jansen, J.H. Marco, de Haij, Simone, Beurskens, Frank J., van der Poel, Cees E., Bevaart, Lisette, Nederend, Maaike, Golay, Josée, van de Winkel, Jan G.J., Parren, Paul W.H.I., Leusen, Jeanette H.W.
Wydane 2011

Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation

od van den Bremer, Ewald TJ, Beurskens, Frank J, Voorhorst, Marleen, Engelberts, Patrick J, de Jong, Rob N, van der Boom, Burt G, Cook, Erika M, Lindorfer, Margaret A, Taylor, Ronald P, van Berkel, Patrick HC, Parren, Paul WHI
Wydane w MAbs (2015)

A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface

od de Jong, Rob N., Beurskens, Frank J., Verploegen, Sandra, Strumane, Kristin, van Kampen, Muriel D., Voorhorst, Marleen, Horstman, Wendy, Engelberts, Patrick J., Oostindie, Simone C., Wang, Guanbo, Heck, Albert J. R., Schuurman, Janine, Parren, Paul W. H. I.
Wydane w PLoS Biol (2016)

Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody

od Gulati, Sunita, Beurskens, Frank J., de Kreuk, Bart-Jan, Roza, Marcel, Zheng, Bo, DeOliveira, Rosane B., Shaughnessy, Jutamas, Nowak, Nancy A., Taylor, Ronald P., Botto, Marina, He, Xianbao, Ingalls, Robin R., Woodruff, Trent M., Song, Wen-Chao, Schuurman, Janine, Rice, Peter A., Ram, Sanjay
Wydane w PLoS Biol (2019)

Single cell sequencing of circulating human plasmablasts during Staphylococcus aureus bacteremia

od Kerkman, Priscilla F., de Vor, Lisanne, van der Vaart, Thomas W., ten Doesschate, Thijs, Muts, Remy M., Depelteau, Jamie S., Scheepmaker, Lisette, Ruyken, Maartje, de Haas, Carla J.C., Aerts, Piet C., Marijnissen, Renoud, Schuurman, Janine, Beurskens, Frank J., Gorlani, Andrea, Bardoel, Bart, Rooijakkers, Suzan H.M.
Wydane w J Immunol (2024)

Hinge-deleted IgG4 blocker therapy for acetylcholine receptor myasthenia gravis in rhesus monkeys

od Losen, Mario, Labrijn, Aran F., van Kranen-Mastenbroek, Vivianne H., Janmaat, Maarten L., Haanstra, Krista G., Beurskens, Frank J., Vink, Tom, Jonker, Margreet, ‘t Hart, Bert A., Mané-Damas, Marina, Molenaar, Peter C., Martinez-Martinez, Pilar, van der Esch, Eline, Schuurman, Janine, de Baets, Marc H., Parren, Paul W. H. I.
Wydane w Sci Rep (2017)

Staphylococcal protein A inhibits complement activation by interfering with IgG hexamer formation

od Cruz, Ana Rita, den Boer, Maurits A., Strasser, Jürgen, Zwarthoff, Seline A., Beurskens, Frank J., de Haas, Carla J. C., Aerts, Piet C., Wang, Guanbo, de Jong, Rob N., Bagnoli, Fabio, van Strijp, Jos A. G., van Kessel, Kok P. M., Schuurman, Janine, Preiner, Johannes, Heck, Albert J. R., Rooijakkers, Suzan H. M.
Wydane w Proc Natl Acad Sci U S A (2021)

CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering

od Oostindie, Simone C., van der Horst, Hilma J., Lindorfer, Margaret A., Cook, Erika M., Tupitza, Jillian C., Zent, Clive S., Burack, Richard, VanDerMeid, Karl R., Strumane, Kristin, Chamuleau, Martine E. D., Mutis, Tuna, de Jong, Rob N., Schuurman, Janine, Breij, Esther C. W., Beurskens, Frank J., Parren, Paul W. H. I., Taylor, Ronald P.
Wydane w Haematologica (2019)

Complement Is Activated by IgG Hexamers Assembled at the Cell Surface

od Diebolder, Christoph A., Beurskens, Frank J., de Jong, Rob N., Koning, Roman I., Strumane, Kristin, Lindorfer, Margaret A., Voorhorst, Marleen, Ugurlar, Deniz, Rosati, Sara, Heck, Albert J. R., van de Winkel, Jan G. J., Wilson, Ian A., Koster, Abraham J., Taylor, Ronald P., Saphire, Erica Ollmann, Burton, Dennis R., Schuurman, Janine, Gros, Piet, Parren, Paul W. H. I.
Wydane w Science (2014)

C1q binding to surface-bound IgG is stabilized by C1r(2)s(2) proteases

od Zwarthoff, Seline A., Widmer, Kevin, Kuipers, Annemarie, Strasser, Jürgen, Ruyken, Maartje, Aerts, Piet C., de Haas, Carla J. C., Ugurlar, Deniz, den Boer, Maurits A., Vidarsson, Gestur, van Strijp, Jos A. G., Gros, Piet, Parren, Paul W. H. I., van Kessel, Kok P. M., Preiner, Johannes, Beurskens, Frank J., Schuurman, Janine, Ricklin, Daniel, Rooijakkers, Suzan H. M.
Wydane w Proc Natl Acad Sci U S A (2021)

DuoHexaBody-CD37(®), a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies

od Oostindie, Simone C., van der Horst, Hilma J., Kil, Laurens P., Strumane, Kristin, Overdijk, Marije B., van den Brink, Edward N., van den Brakel, Jeroen H. N., Rademaker, Hendrik J., van Kessel, Berris, van den Noort, Juliette, Chamuleau, Martine E. D., Mutis, Tuna, Lindorfer, Margaret A., Taylor, Ronald P., Schuurman, Janine, Parren, Paul W. H. I., Beurskens, Frank J., Breij, Esther C. W.
Wydane w Blood Cancer J (2020)