Antibodies That Efficiently Form Hexamers upon Antigen Binding Can Induce Complement-Dependent Cytotoxicity under Complement-Limiting Conditions

Recently, we demonstrated that IgG Abs can organize into ordered hexamers after binding their cognate Ags expressed on cell surfaces. This process is dependent on Fc:Fc interactions, which promote C1q binding, the first step in classical pathway complement activation. We went on to engineer point mu...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Cook, Erika M., Lindorfer, Margaret A., van der Horst, Hilma, Oostindie, Simone, Beurskens, Frank J., Schuurman, Janine, Zent, Clive S., Burack, Richard, Parren, Paul W. H. I., Taylor, Ronald P.
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2016
Assuntos:
Immunotherapy and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991250/
https://ncbi.nlm.nih.gov/pubmed/27474078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600648
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