Induced Resistance to Ofatumumab Mediated Cell Clearance Mechanisms, Including Complement Dependent Cytotoxicity, in Chronic Lymphocytic Leukemia

Ofatumumab (OFA), a human CD20 targeting mAb, kills B-lymphocytes utilizing the innate immune system including complement dependent cytotoxicity (CDC). The efficacy of OFA in patients with chronic lymphocytic leukemia (CLL) is limited by drug resistance, which is not well characterized. To better un...

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Publicado en:J Immunol
Autores principales: Baig, Nisar A., Taylor, Ronald P., Lindorfer, Margaret A., Church, Amy K., LaPlant, Betsy R., Pettinger, Adam M., Shanafelt, Tait D., Nowakowski, Grzegorz S., Zent, Clive S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4391060/
https://ncbi.nlm.nih.gov/pubmed/24431228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302954
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