Direct and Complement Dependent Cytotoxicity in CLL Cells from Patients with High Risk Early Stage Chronic Lymphocytic Leukemia (CLL) Treated with Alemtuzumab and Rituximab

The mechanism of cytotoxicity of alemtuzumab and rituximab in CLL is not well understood. We obtained fresh CLL cells from early stage high risk patients just prior to treatment with alemtuzumab and rituximab to study mechanisms of action and resistance. Alemtuzumab had minimal direct cytotoxicity b...

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Autori principali: Zent, Clive S., Secreto, Charla R., LaPlant, Betsy R., Bone, Nancy D., Call, Timothy G., Shanafelt, Tait D., Jelinek, Diane F., Tschumper, Renee C., Kay, Neil E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2588544/
https://ncbi.nlm.nih.gov/pubmed/18584865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2008.05.014
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