Induced Resistance to Ofatumumab Mediated Cell Clearance Mechanisms, Including Complement Dependent Cytotoxicity, in Chronic Lymphocytic Leukemia

Ofatumumab (OFA), a human CD20 targeting mAb, kills B-lymphocytes utilizing the innate immune system including complement dependent cytotoxicity (CDC). The efficacy of OFA in patients with chronic lymphocytic leukemia (CLL) is limited by drug resistance, which is not well characterized. To better un...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :J Immunol
Главные авторы: Baig, Nisar A., Taylor, Ronald P., Lindorfer, Margaret A., Church, Amy K., LaPlant, Betsy R., Pettinger, Adam M., Shanafelt, Tait D., Nowakowski, Grzegorz S., Zent, Clive S.
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4391060/
https://ncbi.nlm.nih.gov/pubmed/24431228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302954
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы