A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface

IgG antibodies can organize into ordered hexamers on cell surfaces after binding their antigen. These hexamers bind the first component of complement C1 inducing complement-dependent target cell killing. Here, we translated this natural concept into a novel technology platform (HexaBody technology)...

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Vydáno v:PLoS Biol
Hlavní autoři: de Jong, Rob N., Beurskens, Frank J., Verploegen, Sandra, Strumane, Kristin, van Kampen, Muriel D., Voorhorst, Marleen, Horstman, Wendy, Engelberts, Patrick J., Oostindie, Simone C., Wang, Guanbo, Heck, Albert J. R., Schuurman, Janine, Parren, Paul W. H. I.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703389/
https://ncbi.nlm.nih.gov/pubmed/26736041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002344
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