A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface

IgG antibodies can organize into ordered hexamers on cell surfaces after binding their antigen. These hexamers bind the first component of complement C1 inducing complement-dependent target cell killing. Here, we translated this natural concept into a novel technology platform (HexaBody technology)...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: de Jong, Rob N., Beurskens, Frank J., Verploegen, Sandra, Strumane, Kristin, van Kampen, Muriel D., Voorhorst, Marleen, Horstman, Wendy, Engelberts, Patrick J., Oostindie, Simone C., Wang, Guanbo, Heck, Albert J. R., Schuurman, Janine, Parren, Paul W. H. I.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703389/
https://ncbi.nlm.nih.gov/pubmed/26736041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002344
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