Staphylococcal protein A inhibits complement activation by interfering with IgG hexamer formation

Immunoglobulin (Ig) G molecules are essential players in the human immune response against bacterial infections. An important effector of IgG-dependent immunity is the induction of complement activation, a reaction that triggers a variety of responses that help kill bacteria. Antibody-dependent comp...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Cruz, Ana Rita, den Boer, Maurits A., Strasser, Jürgen, Zwarthoff, Seline A., Beurskens, Frank J., de Haas, Carla J. C., Aerts, Piet C., Wang, Guanbo, de Jong, Rob N., Bagnoli, Fabio, van Strijp, Jos A. G., van Kessel, Kok P. M., Schuurman, Janine, Preiner, Johannes, Heck, Albert J. R., Rooijakkers, Suzan H. M.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2021
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7896290/
https://ncbi.nlm.nih.gov/pubmed/33563762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2016772118
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