Exhaustion of cytotoxic effector systems may limit mAb-based immunotherapy in cancer patients()

The CD20 mAb ofatumumab (OFA) induces complement-mediated lysis of B cells. In an investigator-initiated phase II trial of OFA plus chemotherapy for chronic lymphocytic leukemia (CLL), OFA treatment promoted partial CLL B cell depletion which coincided with reduced complement titers. Remaining CLL B...

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Main Authors: Beurskens, Frank J., Lindorfer, Margaret A., Farooqui, Mohammed, Beum, Paul V., Engelberts, Patrick, Mackus, Wendy J.M., Parren, Paul W.H.I., Wiestner, Adrian, Taylor, Ronald P.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311731/
https://ncbi.nlm.nih.gov/pubmed/22368276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1103693
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