Approaches for probing the sequence space of substrates recognized by molecular chaperones

Por Kota, Pradeep, Dokholyan, Nikolay V.
Publicado em 2010

Automated Minimization of Steric Clashes in Protein Structures

Por Ramachandran, Srinivas, Kota, Pradeep, Ding, Feng, Dokholyan, Nikolay V.
Publicado em 2011

Gaia: automated quality assessment of protein structure models

Por Kota, Pradeep, Ding, Feng, Ramachandran, Srinivas, Dokholyan, Nikolay V.
Publicado em 2011

Intra- and Inter-Subunit Disulfide Bond Formation Is Nonessential in Adeno-Associated Viral Capsids

Por Pulicherla, Nagesh, Kota, Pradeep, Dokholyan, Nikolay V., Asokan, Aravind
Publicado em 2012

Dynamics Intrinsic to Cystic Fibrosis Transmembrane Conductance Regulator Function and Stability

Por Chong, P. Andrew, Kota, Pradeep, Dokholyan, Nikolay V., Forman-Kay, Julie D.
Publicado em 2013

Engineered allosteric activation of kinases in living cells

Por Karginov, Andrei V., Ding, Feng, Kota, Pradeep, Dokholyan, Nikolay V., Hahn, Klaus M.
Publicado em 2010

Identification of a consensus motif in substrates bound by a Type I Hsp40

Por Kota, Pradeep, Summers, Daniel W., Ren, Hong-Yu, Cyr, Douglas M., Dokholyan, Nikolay V.
Publicado em 2009

Regulation of the epithelial Na(+) channel and airway surface liquid volume by serine proteases

Por Gaillard, Erol A., Kota, Pradeep, Gentzsch, Martina, Dokholyan, Nikolay V., Stutts, M. Jackson, Tarran, Robert
Publicado em 2010

Energetic and structural basis for activation of the epithelial sodium channel by matriptase

Por Kota, Pradeep, García-Caballero, Agustin, Dang, Hong, Gentzsch, Martina, Stutts, M. Jackson, Dokholyan, Nikolay V.
Publicado em 2012

Rational coupled dynamics network manipulation rescues disease-relevant mutant cystic fibrosis transmembrane conductance regulator

Por Proctor, Elizabeth A., Kota, Pradeep, Aleksandrov, Andrei A., He, Lihua, Riordan, John R., Dokholyan, Nikolay V.
Publicado no Chem Sci (2015)

Correctors of ΔF508 CFTR restore global conformational maturation without thermally stabilizing the mutant protein

Por He, Lihua, Kota, Pradeep, Aleksandrov, Andrei A., Cui, Liying, Jensen, Tim, Dokholyan, Nikolay V., Riordan, John R.
Publicado em 2013

Gain-of-Function Mutation W493R in the Epithelial Sodium Channel Allosterically Reconfigures Intersubunit Coupling

Por Shobair, Mahmoud, Dagliyan, Onur, Kota, Pradeep, Dang, Yan L., He, Hong, Stutts, M. Jackson, Dokholyan, Nikolay V.
Publicado no J Biol Chem (2016)

Light-regulation of protein dimerization and kinase activity in living cells using photocaged rapamycin and engineered FKBP

Por Karginov, Andrei V., Zou, Yan, Shirvanyants, David, Kota, Pradeep, Dokholyan, Nikolay V., Young, Douglas D., Hahn, Klaus M., Deiters, Alexander
Publicado em 2010

Regulatory insertion removal restores maturation, stability and function of ΔF508 CFTR

Por Aleksandrov, Andrei A., Kota, Pradeep, Aleksandrov, Luba A., He, Lihua, Jensen, Tim, Cui, Liying, Gentzsch, Martina, Dokholyan, Nikolay V., Riordan, John R.
Publicado no J Mol Biol (2010)

Computational approaches to understanding protein aggregation in neurodegeneration

Por Redler, Rachel L., Shirvanyants, David, Dagliyan, Onur, Ding, Feng, Kim, Doo Nam, Kota, Pradeep, Proctor, Elizabeth A., Ramachandran, Srinivas, Tandon, Arpit, Dokholyan, Nikolay V.
Publicado em 2014

The N-terminal Domain Allosterically Regulates Cleavage and Activation of the Epithelial Sodium Channel

Por Kota, Pradeep, Buchner, Ginka, Chakraborty, Hirak, Dang, Yan L., He, Hong, Garcia, Guilherme J. M., Kubelka, Jan, Gentzsch, Martina, Stutts, M. Jackson, Dokholyan, Nikolay V.
Publicado em 2014

Allosteric modulation balances thermodynamic stability and restores function of ΔF508 CFTR

Por Aleksandrov, Andrei A., Kota, Pradeep, Cui, Liying, Jensen, Tim, Alekseev, Alexey E., Reyes, Santiago, He, Lihua, Gentzsch, Martina, Aleksandrov, Luba A., Dokholyan, Nikolay V., Riordan, John R.
Publicado em 2012

Identification of a new actin binding surface on vinculin that mediates mechanical cell and focal adhesion properties

Por Thompson, Peter M., Tolbert, Caitlin E., Shen, Kai, Kota, Pradeep, Palmer, Sean M., Plevock, Karen M., Orlova, Albina, Galkin, Vitold E., Burridge, Keith, Egelman, Edward H., Dokholyan, Nikolay V., Superfine, Richard, Campbell, Sharon L.
Publicado em 2014