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Dynamics Intrinsic to Cystic Fibrosis Transmembrane Conductance Regulator Function and Stability

The cystic fibrosis transmembrane conductance regulator (CFTR) requires dynamic fluctuations between states in its gating cycle for proper channel function, including changes in the interactions between the nucleotide-binding domains (NBDs) and between the intracellular domain (ICD) coupling helices...

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Detalhes bibliográficos
Main Authors: Chong, P. Andrew, Kota, Pradeep, Dokholyan, Nikolay V., Forman-Kay, Julie D.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579207/
https://ncbi.nlm.nih.gov/pubmed/23457292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a009522
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