Binding screen for cystic fibrosis transmembrane conductance regulator correctors finds new chemical matter and yields insights into cystic fibrosis therapeutic strategy

The most common mutation in cystic fibrosis (CF) patients is deletion of F508 (ΔF508) in the first nucleotide binding domain (NBD1) of the CF transmembrane conductance regulator (CFTR). ΔF508 causes a decrease in the trafficking of CFTR to the cell surface and reduces the thermal stability of isolat...

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Veröffentlicht in:Protein Sci
Hauptverfasser: Hall, Justin D., Wang, Hong, Byrnes, Laura J., Shanker, Suman, Wang, Kelong, Efremov, Ivan V., Chong, P. Andrew, Forman‐Kay, Julie D., Aulabaugh, Ann E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4815353/
https://ncbi.nlm.nih.gov/pubmed/26444971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2821
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