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Approaches for probing the sequence space of substrates recognized by molecular chaperones

Neurodegeneration, the progressive loss of function in neurons that eventually leads to their death, is the cause of many neurodegenerative disorders including Alzheimer’s, Parkinson’s, and Huntington’s diseases. Protein aggregation is a hallmark of most neurodegenerative diseases, where unfolded pr...

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Detalhes bibliográficos
Main Authors: Kota, Pradeep, Dokholyan, Nikolay V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057280/
https://ncbi.nlm.nih.gov/pubmed/21195183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymeth.2010.12.034
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