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Correctors of ΔF508 CFTR restore global conformational maturation without thermally stabilizing the mutant protein
Most cystic fibrosis is caused by the deletion of a single amino acid (F508) from CFTR and the resulting misfolding and destabilization of the protein. Compounds identified by high-throughput screening to improve ΔF508 CFTR maturation have already entered clinical trials, and it is important to unde...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Federation of American Societies for Experimental Biology
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3545534/ https://ncbi.nlm.nih.gov/pubmed/23104983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-216119 |
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