Restoration of NBD1 thermal stability is necessary and sufficient to correct ΔF508 CFTR folding and assembly

CFTR (ABCC7), unique among ABC exporters as an ion channel, regulates ion and fluid transport in epithelial tissues. Loss of function due to mutations in the cftr gene causes cystic fibrosis (CF). The most common CF-causing mutation, the deletion of F508 (ΔF508) from the first nucleotide binding dom...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Mol Biol
Main Authors: He, Lihua, Aleksandrov, Andrei A, An, Jianli, Cui, Liying, Yang, Zhengrong, Brouillette, Christie G., Riordan, John R
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4757845/
https://ncbi.nlm.nih.gov/pubmed/25083918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2014.07.026
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados