Correction of both NBD1 energetics and domain interface is required to restore ΔF508 CFTR folding and function

The folding and misfolding mechanism of multi-domain proteins remains poorly understood. While thermodynamic instability of the first nucleotide binding domain (NBD1) of ΔF508-CFTR partly accounts for the mutant channel degradation in the endoplasmic reticulum and is considered as a drug target in c...

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Autors principals: Rabeh, Wael M., Bossard, Florian, Xu, Haijin, Okiyoneda, Tsukasa, Bagdany, Miklos, Mulvihill, Cory M., Du, Kai, di Bernardo, Salvatore, Liu, Yuhong, Konermann, Lars, Roldan, Ariel, Lukacs, Gergely L.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431169/
https://ncbi.nlm.nih.gov/pubmed/22265408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.11.024
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