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Peripheral Protein Quality Control Removes Unfolded CFTR from the Plasma Membrane
Therapeutic efforts to restore biosynthetic processing of the cystic fibrosis transmembrane conductance regulator lacking the F508 residue (ΔF508CFTR) are hampered by ubiquitin-dependent lysosomal degradation of nonnative, rescued ΔF508CFTR from the plasma membrane. Here, functional small interferin...
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| Vydáno v: | Science |
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| Hlavní autoři: | , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5026491/ https://ncbi.nlm.nih.gov/pubmed/20595578 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1191542 |
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