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Restoration of NBD1 thermal stability is necessary and sufficient to correct ΔF508 CFTR folding and assembly
CFTR (ABCC7), unique among ABC exporters as an ion channel, regulates ion and fluid transport in epithelial tissues. Loss of function due to mutations in the cftr gene causes cystic fibrosis (CF). The most common CF-causing mutation, the deletion of F508 (ΔF508) from the first nucleotide binding dom...
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| Udgivet i: | J Mol Biol |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4757845/ https://ncbi.nlm.nih.gov/pubmed/25083918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2014.07.026 |
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