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Regulatory insertion removal restores maturation, stability and function of ΔF508 CFTR
The cystic fibrosis transmembrane conductance regulator (CFTR) epithelial anion channel is a large multi-domain membrane protein which matures inefficiently during biosynthesis. Its assembly is further perturbed by the deletion of F508 from the first nucleotide binding domain (NBD1) responsible for...
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| 發表在: | J Mol Biol |
|---|---|
| Main Authors: | , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4361937/ https://ncbi.nlm.nih.gov/pubmed/20561529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.06.019 |
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