Regulatory insertion removal restores maturation, stability and function of ΔF508 CFTR

The cystic fibrosis transmembrane conductance regulator (CFTR) epithelial anion channel is a large multi-domain membrane protein which matures inefficiently during biosynthesis. Its assembly is further perturbed by the deletion of F508 from the first nucleotide binding domain (NBD1) responsible for...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Mol Biol
Prif Awduron: Aleksandrov, Andrei A., Kota, Pradeep, Aleksandrov, Luba A., He, Lihua, Jensen, Tim, Cui, Liying, Gentzsch, Martina, Dokholyan, Nikolay V., Riordan, John R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4361937/
https://ncbi.nlm.nih.gov/pubmed/20561529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.06.019
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg