Regulatory insertion removal restores maturation, stability and function of ΔF508 CFTR

The cystic fibrosis transmembrane conductance regulator (CFTR) epithelial anion channel is a large multi-domain membrane protein which matures inefficiently during biosynthesis. Its assembly is further perturbed by the deletion of F508 from the first nucleotide binding domain (NBD1) responsible for...

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Veröffentlicht in:J Mol Biol
Hauptverfasser: Aleksandrov, Andrei A., Kota, Pradeep, Aleksandrov, Luba A., He, Lihua, Jensen, Tim, Cui, Liying, Gentzsch, Martina, Dokholyan, Nikolay V., Riordan, John R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4361937/
https://ncbi.nlm.nih.gov/pubmed/20561529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.06.019
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